1,7-Palladium Migration via C−H Activation, Followed by Intramolecular Amination: Regioselective Synthesis of Benzotriazoles

1,7-Palladium Migration via C−H Activation, Followed by Intramolecular Amination: Regioselective Synthesis of Benzotriazoles

A novel 1,7-palladium migration−cyclization−dealkylation sequence for the regioselective synthesis of benzotriazoles has been developed. These reactions proceed in excellent yields with high regioselectivities. The mechanism of the reaction has also been investigated.

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Veröffentlicht in:Journal of the American Chemical Society 2011-05, Vol.133 (18), p.6868-6870
Hauptverfasser: Zhou, Jun, He, Jianjun, Wang, Binjie, Yang, Weijun, Ren, Hongjun
Format: Artikel
Sprache:eng
Schlagworte:
Amination
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Cyclization
Palladium - chemistry
Triazoles - chemical synthesis
Triazoles - chemistry
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Beschreibung
Zusammenfassung:A novel 1,7-palladium migration−cyclization−dealkylation sequence for the regioselective synthesis of benzotriazoles has been developed. These reactions proceed in excellent yields with high regioselectivities. The mechanism of the reaction has also been investigated.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja2007438