Hepatic Non-Hodgkin’s Lymphoma With Lactic Acidosis in HIV-Infected Patients: Report of 2 Cases

We report 2 patients with HIV-associated non-Hodgkin’s lymphoma with massive hepatic involvement and lactic acidosis. The lactic acidosis was likely caused by excessive tumor lactate production coupled with impaired hepatic clearance. Although 1 patient died rapidly, the other survived for 7 months...

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Veröffentlicht in:	Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Ill. : 2002), 2010-09, Vol.9 (5), p.301-305
Hauptverfasser:	Kestler, Mary H., Gardner, Edward M., Cohn, David L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis, Lactic - etiology Adult Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antiretroviral drugs Cyclophosphamide - therapeutic use Doxorubicin - therapeutic use Fatal Outcome HIV Human immunodeficiency virus Humans Liver Neoplasms - complications Liver Neoplasms - drug therapy Liver Neoplasms - pathology Lymphoma Lymphoma, AIDS-Related - complications Lymphoma, AIDS-Related - drug therapy Lymphoma, AIDS-Related - pathology Male Middle Aged Patients Prednisone - therapeutic use Vincristine - therapeutic use
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Zusammenfassung:	We report 2 patients with HIV-associated non-Hodgkin’s lymphoma with massive hepatic involvement and lactic acidosis. The lactic acidosis was likely caused by excessive tumor lactate production coupled with impaired hepatic clearance. Although 1 patient died rapidly, the other survived for 7 months after receiving urgent combination chemotherapy. Clinicians should be aware of this condition and the importance of its early diagnosis and treatment.
ISSN:	1545-1097 2325-9574 1557-0886 2325-9582
DOI:	10.1177/1545109710377803