What turns on Foxp3?
Inducible regulatory T cells respond to TGF-β by upregulating Foxp3 expression. Tone and colleagues identify an enhancer site in Foxp3 that binds transcription factors Smad3 and NFAT, suggesting a means by which TGF-β regulates Foxp3 expression.
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| Veröffentlicht in: | Nature immunology 2008-02, Vol.9 (2), p.121-122 |
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| container_title | Nature immunology |
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| creator | von Boehmer, Harald Nolting, Jens |
| description | Inducible regulatory T cells respond to TGF-β by upregulating Foxp3 expression. Tone and colleagues identify an enhancer site in
Foxp3
that binds transcription factors Smad3 and NFAT, suggesting a means by which TGF-β regulates Foxp3 expression. |
| doi_str_mv | 10.1038/ni0208-121 |
| format | Article |
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| ispartof | Nature immunology, 2008-02, Vol.9 (2), p.121-122 |
| issn | 1529-2908 1529-2916 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_864953321 |
| source | MEDLINE; Nature; Springer Nature - Complete Springer Journals |
| subjects | Biomedical and Life Sciences Biomedicine Enhancer Elements, Genetic Forkhead Transcription Factors - genetics Gene Expression Regulation Humans Immunology Infectious Diseases news-and-views NFATC Transcription Factors - metabolism Promoter Regions, Genetic Smad3 Protein - metabolism T-Lymphocytes, Regulatory - immunology Transforming Growth Factor alpha - metabolism Transforming Growth Factor alpha - pharmacology |
| title | What turns on Foxp3? |
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