What turns on Foxp3?

Inducible regulatory T cells respond to TGF-β by upregulating Foxp3 expression. Tone and colleagues identify an enhancer site in Foxp3 that binds transcription factors Smad3 and NFAT, suggesting a means by which TGF-β regulates Foxp3 expression.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2008-02, Vol.9 (2), p.121-122
Hauptverfasser:	von Boehmer, Harald, Nolting, Jens
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Enhancer Elements, Genetic Forkhead Transcription Factors - genetics Gene Expression Regulation Humans Immunology Infectious Diseases news-and-views NFATC Transcription Factors - metabolism Promoter Regions, Genetic Smad3 Protein - metabolism T-Lymphocytes, Regulatory - immunology Transforming Growth Factor alpha - metabolism Transforming Growth Factor alpha - pharmacology
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Beschreibung
Zusammenfassung:	Inducible regulatory T cells respond to TGF-β by upregulating Foxp3 expression. Tone and colleagues identify an enhancer site in Foxp3 that binds transcription factors Smad3 and NFAT, suggesting a means by which TGF-β regulates Foxp3 expression.
ISSN:	1529-2908 1529-2916
DOI:	10.1038/ni0208-121