Rett syndrome model suggests MECP2 gives neurons the quiet they need to think

The neurodevelopmental disorder Rett syndrome involves mutations in the transcriptional repressor MECP2. Two groups now show a role for MECP2 in postmitotic mouse neurons.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature neuroscience 2001-04, Vol.4 (4), p.342-343
Hauptverfasser:	Carter, Alexandre R, Segal, Rosalind A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Care and treatment Chromosomal Proteins, Non-Histone Disease Models, Animal DNA Methylation DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Female Gene mutations Genetic aspects Health aspects Humans Male Methyl-CpG-Binding Protein 2 Mice Mutation Neurobiology Neurons Neurons - physiology Neurosciences news-and-views Physiological aspects Repressor Proteins Rett syndrome Rett Syndrome - genetics Rett Syndrome - physiopathology Risk factors
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Beschreibung
Zusammenfassung:	The neurodevelopmental disorder Rett syndrome involves mutations in the transcriptional repressor MECP2. Two groups now show a role for MECP2 in postmitotic mouse neurons.
ISSN:	1097-6256 1546-1726
DOI:	10.1038/85970