Innate inflammatory response to the malarial pigment hemozoin

Malaria is an infectious disease caused by parasites of the genus Plasmodium. This intraerythrocytic protozoan produces hemozoin (HZ), an insoluble crystalline metabolite resulting from the heme detoxification mechanism. This review will focus on HZ biosynthesis and synthetic preparation, but in par...

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Veröffentlicht in:Microbes and infection 2010-11, Vol.12 (12-13), p.889-899
Hauptverfasser: Shio, Marina T., Kassa, Fikregabrail A., Bellemare, Marie-Josée, Olivier, Martin
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container_end_page 899
container_issue 12-13
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container_title Microbes and infection
container_volume 12
creator Shio, Marina T.
Kassa, Fikregabrail A.
Bellemare, Marie-Josée
Olivier, Martin
description Malaria is an infectious disease caused by parasites of the genus Plasmodium. This intraerythrocytic protozoan produces hemozoin (HZ), an insoluble crystalline metabolite resulting from the heme detoxification mechanism. This review will focus on HZ biosynthesis and synthetic preparation, but in particular on its effect on host’s innate inflammatory responses.
doi_str_mv 10.1016/j.micinf.2010.07.001
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source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Biological and medical sciences
Biosynthesis
Chemokines
Cytokines
Fundamental and applied biological sciences. Psychology
Hematin anhydride
Hemeproteins - biosynthesis
Hemeproteins - chemical synthesis
Hemeproteins - immunology
Hemozoin
Human protozoal diseases
Humans
Immunity, Innate
Infectious diseases
Inflammation - immunology
Innate immune response
Macrophages
Malaria
Medical sciences
Microbiology
NLR
Parasitic diseases
Plasmodium
Plasmodium - immunology
Protozoal diseases
TLR
title Innate inflammatory response to the malarial pigment hemozoin
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