Innate inflammatory response to the malarial pigment hemozoin
Malaria is an infectious disease caused by parasites of the genus Plasmodium. This intraerythrocytic protozoan produces hemozoin (HZ), an insoluble crystalline metabolite resulting from the heme detoxification mechanism. This review will focus on HZ biosynthesis and synthetic preparation, but in par...
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Veröffentlicht in: | Microbes and infection 2010-11, Vol.12 (12-13), p.889-899 |
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creator | Shio, Marina T. Kassa, Fikregabrail A. Bellemare, Marie-Josée Olivier, Martin |
description | Malaria is an infectious disease caused by parasites of the genus Plasmodium. This intraerythrocytic protozoan produces hemozoin (HZ), an insoluble crystalline metabolite resulting from the heme detoxification mechanism. This review will focus on HZ biosynthesis and synthetic preparation, but in particular on its effect on host’s innate inflammatory responses. |
doi_str_mv | 10.1016/j.micinf.2010.07.001 |
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This intraerythrocytic protozoan produces hemozoin (HZ), an insoluble crystalline metabolite resulting from the heme detoxification mechanism. This review will focus on HZ biosynthesis and synthetic preparation, but in particular on its effect on host’s innate inflammatory responses.</description><identifier>ISSN: 1286-4579</identifier><identifier>EISSN: 1769-714X</identifier><identifier>DOI: 10.1016/j.micinf.2010.07.001</identifier><identifier>PMID: 20637890</identifier><language>eng</language><publisher>Kidlington: Elsevier Masson SAS</publisher><subject>Biological and medical sciences ; Biosynthesis ; Chemokines ; Cytokines ; Fundamental and applied biological sciences. Psychology ; Hematin anhydride ; Hemeproteins - biosynthesis ; Hemeproteins - chemical synthesis ; Hemeproteins - immunology ; Hemozoin ; Human protozoal diseases ; Humans ; Immunity, Innate ; Infectious diseases ; Inflammation - immunology ; Innate immune response ; Macrophages ; Malaria ; Medical sciences ; Microbiology ; NLR ; Parasitic diseases ; Plasmodium ; Plasmodium - immunology ; Protozoal diseases ; TLR</subject><ispartof>Microbes and infection, 2010-11, Vol.12 (12-13), p.889-899</ispartof><rights>2010 Institut Pasteur</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Institut Pasteur. Published by Elsevier SAS. 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This intraerythrocytic protozoan produces hemozoin (HZ), an insoluble crystalline metabolite resulting from the heme detoxification mechanism. This review will focus on HZ biosynthesis and synthetic preparation, but in particular on its effect on host’s innate inflammatory responses.</description><subject>Biological and medical sciences</subject><subject>Biosynthesis</subject><subject>Chemokines</subject><subject>Cytokines</subject><subject>Fundamental and applied biological sciences. 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subjects | Biological and medical sciences Biosynthesis Chemokines Cytokines Fundamental and applied biological sciences. Psychology Hematin anhydride Hemeproteins - biosynthesis Hemeproteins - chemical synthesis Hemeproteins - immunology Hemozoin Human protozoal diseases Humans Immunity, Innate Infectious diseases Inflammation - immunology Innate immune response Macrophages Malaria Medical sciences Microbiology NLR Parasitic diseases Plasmodium Plasmodium - immunology Protozoal diseases TLR |
title | Innate inflammatory response to the malarial pigment hemozoin |
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