Variation in complement factor 3 is associated with risk of age-related macular degeneration

The association of variants in complement factors H and B with age-related macular degeneration has led to more intense genetic and functional analysis of the complement pathway. We identify a nonsynonymous coding change in complement factor 3 that is strongly associated with risk of age-related mac...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature genetics 2007-10, Vol.39 (10), p.1200-1201
Hauptverfasser:	Daly, Mark J, Seddon, Johanna M, Maller, Julian B, Fagerness, Jesen A, Reynolds, Robyn C, Neale, Benjamin M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Biological and medical sciences Case-Control Studies Complement C3 - genetics Fundamental and applied biological sciences. Psychology Genetic aspects Genetic Variation Genetics Genetics of eukaryotes. Biological and molecular evolution Humans Macular degeneration Macular Degeneration - genetics Medical sciences Ophthalmology Physiological aspects Retinopathies Risk Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The association of variants in complement factors H and B with age-related macular degeneration has led to more intense genetic and functional analysis of the complement pathway. We identify a nonsynonymous coding change in complement factor 3 that is strongly associated with risk of age-related macular degeneration in a large case-control sample.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng2131