Diversity of microRNAs in human and chimpanzee brain

We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyond primates, indicating their recent origin, and some miRNAs seem species specific, whereas others are exp...

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Veröffentlicht in:	Nature genetics 2006-12, Vol.38 (12), p.1375-1377
Hauptverfasser:	Plasterk, Ronald H A, Berezikov, Eugene, Thuemmler, Fritz, van Laake, Linda W, Kondova, Ivanela, Bontrop, Ronald, Cuppen, Edwin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain Brain - metabolism Cloning, Molecular Conserved Sequence Distribution DNA sequencing Evolution Evolution, Molecular Fundamental and applied biological sciences. Psychology Genetic aspects Genetic diversity Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Hominids Humans Methods MicroRNAs - genetics Monkeys & apes Nucleotide sequencing Pan troglodytes Pan troglodytes - genetics Physiological aspects Primates Ribonucleic acid RNA Species Specificity
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Beschreibung
Zusammenfassung:	We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyond primates, indicating their recent origin, and some miRNAs seem species specific, whereas others are expanded in one species through duplication events. These data suggest that evolution of miRNAs is an ongoing process and that along with ancient, highly conserved miRNAs, there are a number of emerging miRNAs.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng1914