Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation

Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation o...

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Veröffentlicht in:	Nature neuroscience 2006-05, Vol.9 (5), p.602-604
Hauptverfasser:	Plant, Karen, Pelkey, Kenneth A, Bortolotto, Zuner A, Morita, Daiju, Terashima, Akira, McBain, Chris J, Collingridge, Graham L, Isaac, John T R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Animals, Newborn Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine brief-communication Calcium - metabolism Dose-Response Relationship, Radiation Electric Stimulation - methods Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Excitatory Postsynaptic Potentials - radiation effects Hippocampus (Brain) Hippocampus - cytology In Vitro Techniques Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Long-Term Potentiation - radiation effects Mice Neural receptors Neural transmission Neurobiology Neurosciences Nicotinic Antagonists - pharmacology Patch-Clamp Techniques - methods Physiological aspects Polyamines - pharmacology Pyramidal Cells - drug effects Pyramidal Cells - physiology Pyramidal Cells - radiation effects Rats Receptors, AMPA - chemistry Receptors, AMPA - deficiency Receptors, AMPA - physiology Time Factors
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Zusammenfassung:	Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs ∼25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.
ISSN:	1097-6256 1546-1726
DOI:	10.1038/nn1678