LEF1 turns over a new leaf

LEF and TCF transcription factors (referred to collectively as LEF/TCFs) are pivotal players in the molecular pathology of cancer of the intestinal tract. Mutant components of the Wnt signal transduction cascade invariably lead to the inappropriate activation of LEF/TCFs in the cancer cell. A new st...

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Veröffentlicht in:	Nature genetics 2001-05, Vol.28 (1), p.3-4
Hauptverfasser:	Lau, Wim de, Clevers, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics beta Catenin Biomedical and Life Sciences Biomedicine Cancer Research Colorectal carcinoma Colorectal Neoplasms - etiology Cytoskeletal Proteins - isolation & purification DNA-Binding Proteins - metabolism Gene Function Human Genetics Intestinal Mucosa - metabolism Intestinal Neoplasms - etiology Lymphoid Enhancer-Binding Factor 1 news-and-views Proto-Oncogene Proteins - metabolism Signal Transduction Trans-Activators Transcription Factors - metabolism Wnt Proteins Zebrafish Proteins
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Beschreibung
Zusammenfassung:	LEF and TCF transcription factors (referred to collectively as LEF/TCFs) are pivotal players in the molecular pathology of cancer of the intestinal tract. Mutant components of the Wnt signal transduction cascade invariably lead to the inappropriate activation of LEF/TCFs in the cancer cell. A new study provides evidence for an unexpected amplification step in this cascade. The inappropriate activity of the Wnt pathway in colorectal cancer cells induces the expression of LEF1, which is normally not expressed in intestinal epithelium.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng0501-3