Expression of 5-HT2A and 5-HT1B receptor mRNA in blood vessels

Expression of two subtypes of 5-hydroxytryptamine (5-HT) receptors, 5-HT1B and 5-HT2A, was investigated in normal rat arteries (abdominal aorta) and veins (inferior vena cava) by the quantitative reverse transcription-polymerase chain reaction (RT-PCR). The arterial 5-HT2A receptor mRNA level in art...

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Veröffentlicht in:	Molecular and cellular biochemistry 1999-09, Vol.199 (1-2), p.57-61
Hauptverfasser:	Kato, S, Kumamoto, H, Hirano, M, Akiyama, H, Kaneko, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteries - physiology Blood Vessels - chemistry Fluorescent Dyes - analysis Glyceraldehyde-3-Phosphate Dehydrogenases - genetics Male Molecular Weight Peptide Fragments - genetics Rats Rats, Sprague-Dawley Receptor, Serotonin, 5-HT1B Receptor, Serotonin, 5-HT2A Receptors, Serotonin - genetics Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - analysis Rodents Sequence Analysis, DNA - instrumentation Sequence Analysis, DNA - methods Veins - physiology
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Zusammenfassung:	Expression of two subtypes of 5-hydroxytryptamine (5-HT) receptors, 5-HT1B and 5-HT2A, was investigated in normal rat arteries (abdominal aorta) and veins (inferior vena cava) by the quantitative reverse transcription-polymerase chain reaction (RT-PCR). The arterial 5-HT2A receptor mRNA level in artery was 25-fold (p < 0.01) higher than the venous level, and the arterial 5-HT1B receptor mRNA level was at least 7000-fold (p < 0.005) higher the venous level.
ISSN:	0300-8177 1573-4919
DOI:	10.1023/A:1006999031932