Copper-Catalyzed C-P Coupling through Decarboxylation

Copper-Catalyzed C-P Coupling through Decarboxylation

An acid for a phosphine: A versatile protocol for preparation of various di(phenyl)phosphoryl oxides was developed by copper‐catalyzed decarboxylative coupling of alkenyl, alkynyl carboxylic acids, and N‐benzylproline, respectively, with R2P(O)H (see scheme). All classes of products are important pr...

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Veröffentlicht in:Chemistry : a European journal 2011-05, Vol.17 (20), p.5516-5521
Hauptverfasser: Hu, Jie, Zhao, Ning, Yang, Bin, Wang, Ge, Guo, Li-Na, Liang, Yong-Min, Yang, Shang-Dong
Format: Artikel
Sprache:eng
Schlagworte:
C-P coupling
Catalysis
Chemistry
Combinatorial Chemistry Techniques
copper
Copper - chemistry
Decarboxylation
Molecular Structure
Organophosphorus Compounds - chemical synthesis
Organophosphorus Compounds - chemistry
phosphorus
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Zusammenfassung:An acid for a phosphine: A versatile protocol for preparation of various di(phenyl)phosphoryl oxides was developed by copper‐catalyzed decarboxylative coupling of alkenyl, alkynyl carboxylic acids, and N‐benzylproline, respectively, with R2P(O)H (see scheme). All classes of products are important precursors for preparation of biologically active molecules and various phosphorus ligands. This finding represents the first example of copper‐catalyzed decarboxylative coupling to construct CP bonds.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201003561