Diagnosing TB infection in children: analysis of discordances using in vitro tests and the tuberculin skin test

Diagnosing TB infection in children: analysis of discordances using in vitro tests and the tuberculin skin test

The aim of the present study was to compare the performance of the interferon (IFN)-γ tests (QuantiFERON®-TB Gold In-Tube (QFT-G-IT) and T-SPOT®.TB) with the tuberculin skin test (TST) in diagnosing tuberculosis (TB) infection in children, and to analyse discordant results. This was a prospective st...

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Veröffentlicht in:The European respiratory journal 2011-05, Vol.37 (5), p.1166-1174
Hauptverfasser: Altet-Gómez, N, De Souza-Galvao, M, Latorre, I, Milà, C, Jiménez, M A, Solsona, J, Cantos, A, Zamora, J J, Ruiz-Manzano, J, Ausina, V, Domínguez, J
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
BCG Vaccine - immunology
Child
Child, Preschool
Contact Tracing
Female
Humans
Interferon-gamma - secretion
Male
Mass Screening
Prospective Studies
Sensitivity and Specificity
T-Lymphocytes - immunology
Tuberculin Test
Tuberculosis - diagnosis
Tuberculosis - immunology
Tuberculosis - prevention & control
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Zusammenfassung:The aim of the present study was to compare the performance of the interferon (IFN)-γ tests (QuantiFERON®-TB Gold In-Tube (QFT-G-IT) and T-SPOT®.TB) with the tuberculin skin test (TST) in diagnosing tuberculosis (TB) infection in children, and to analyse discordant results. This was a prospective study including 98 children from contact-tracing studies and 68 children with TST indurations ≥ 5 mm recruited during public health screenings. Positive IFN-γ tests results were associated with risk of exposure (p
ISSN:0903-1936
1399-3003
DOI:10.1183/09031936.00022710