Toward a global classification of mast cell activation diseases

According to recent findings,3-5 the specific biochemical and immunohistochemical pathological alterations of mast cells in systemic mastocytosis (SM) defined by the World Health Organization (WHO) criteria (SM-WHO) are a result of the presence of the D816V mutation in tyrosine kinase Kit.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of allergy and clinical immunology 2011-05, Vol.127 (5), p.1311-1311
Hauptverfasser:	Molderings, Gerhard J., MD, Homann, Jürgen, MD, Raithel, Martin, MD, Frieling, Thomas, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Cytokines Disease Histamine Humans Mast Cells - immunology Mast Cells - metabolism Mast Cells - pathology Mastocytosis, Systemic - classification Mastocytosis, Systemic - immunology Mastocytosis, Systemic - physiopathology Mutation Syndrome T cell receptors World Health Organization
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Beschreibung
Zusammenfassung:	According to recent findings,3-5 the specific biochemical and immunohistochemical pathological alterations of mast cells in systemic mastocytosis (SM) defined by the World Health Organization (WHO) criteria (SM-WHO) are a result of the presence of the D816V mutation in tyrosine kinase Kit.
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2010.12.1113