An efficient HCCP-mediated direct amination of quinazolin-4(3 H)-ones

An efficient HCCP-mediated direct amination of quinazolin-4(3 H)-ones

An efficient direct amination of quinazolin-4(3 H)-ones has been developed. Treatment of quinazolin-4(3 H)-ones with HCCP, DIPEA, and N-contained nucleophiles in acetonitrile could be able to form the corresponding 4-aminoquinazoline derivatives. Under the optimal reaction conditions, the amination...

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Veröffentlicht in:Engineering fracture mechanics 2011-03, Vol.67 (9), p.1665-1672
Hauptverfasser: Shen, Zhenlu, He, Xiaofei, Dai, Jialiang, Mo, Weimin, Hu, Baoxiang, Sun, Nan, Hu, Xinquan
Format: Artikel
Sprache:eng
Schlagworte:
4-Aminoquinazolines
Acetonitrile
Amination
Chemistry
Derivatives
Exact sciences and technology
Fracture mechanics
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Hexachlorocyclotriphosphazene
Nucleophiles
Optimization
Organic chemistry
Preparations and properties
Quinazolin-4(3 H)-ones
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Zusammenfassung:An efficient direct amination of quinazolin-4(3 H)-ones has been developed. Treatment of quinazolin-4(3 H)-ones with HCCP, DIPEA, and N-contained nucleophiles in acetonitrile could be able to form the corresponding 4-aminoquinazoline derivatives. Under the optimal reaction conditions, the amination products were achieved in good yields. [Display omitted]
ISSN:0040-4020
0013-7944
1464-5416
DOI:10.1016/j.tet.2010.12.067