Leptin and the central nervous system control of glucose metabolism

The regulation of body fat stores and blood glucose levels is critical for survival. This review highlights growing evidence that leptin action in the central nervous system plays a key role in both processes. Investigation into underlying mechanisms has begun to clarify the physiological role of le...

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Veröffentlicht in:	Physiological reviews 2011-04, Vol.91 (2), p.389-411
Hauptverfasser:	Morton, Gregory J, Schwartz, Michael W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Adiposity - physiology Animals Body fat Central Nervous System - physiology Diabetes Diabetes Mellitus - metabolism Glucose Glucose - metabolism Homeostasis - physiology Humans Insulin - physiology Janus Kinases - metabolism Leptin - physiology Medical treatment Metabolism Nerve Net - physiology Nervous system Nutritional Physiological Phenomena Obesity - metabolism Phosphatidylinositol 3-Kinases - metabolism Signal Transduction - physiology
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Beschreibung
Zusammenfassung:	The regulation of body fat stores and blood glucose levels is critical for survival. This review highlights growing evidence that leptin action in the central nervous system plays a key role in both processes. Investigation into underlying mechanisms has begun to clarify the physiological role of leptin in the control of glucose metabolism and raises interesting new possibilities for the treatment of diabetes and related disorders.
ISSN:	0031-9333 1522-1210
DOI:	10.1152/physrev.00007.2010