Palladium-catalyzed C-H bond functionalization of C6-arylpurines

Palladium-catalyzed C-H bond functionalization of C6-arylpurines

A highly regioselective Pd-catalyzed C(Ar)-H bond activation method was developed for the modification of purines (nucleosides) with different functional groups by using purine as a directing group. This approach provides a new access to a variety of functionalized purines (nucleosides) which are po...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2011-05, Vol.47 (19), p.5608-5610
Hauptverfasser: Guo, Hai-Ming, Rao, Wei-Hao, Niu, Hong-Ying, Jiang, Li-Li, Meng, Ge, Jin, Jia-Jia, Yang, Xi-Ning, Qu, Gui-Rong
Format: Artikel
Sprache:eng
Schlagworte:
Carbon - chemistry
Catalysis
Hydrogen - chemistry
Palladium - chemistry
Purines - chemistry
Stereoisomerism
Substrate Specificity
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Beschreibung
Zusammenfassung:A highly regioselective Pd-catalyzed C(Ar)-H bond activation method was developed for the modification of purines (nucleosides) with different functional groups by using purine as a directing group. This approach provides a new access to a variety of functionalized purines (nucleosides) which are potentially of great importance in medicinal chemistry.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc11135c