A prospective observational study of treatment practice patterns in acute coronary syndrome patients undergoing percutaneous coronary intervention in Europe

Summary Background The AntiPlatelet Therapy Observational Registry (APTOR) was a prospective observational study of acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) in France, Spain, and the UK. Aims To evaluate patterns of ACS healthcare use, focusing on APTOR results from France. Methods Consecutive presenting ACS patients requiring PCI were recruited between January and August 2007. Treatments and outcomes were recorded from the qualifying ACS event to 12 months follow-up. Results In France, qualifying diagnosis was unstable angina/non-ST-segment elevation myocardial infarction (UA/NSTEMI) in 255 (53%) patients and ST-segment elevation myocardial infarction (STEMI) in 228 (47%) patients. Ninety-six percent underwent PCI with stent implantation. Drug eluting stents were used less frequently in France (22%) than Spain (54%) or the UK (42%). In France, antiplatelets were more frequently received in the ambulance (21%); a 200–299 mg aspirin-loading dose was most frequently received (50%) and more than a third of patients received a clopidogrel-loading dose of over 300 mg (34%). At 12 months in France, 86% were still receiving aspirin, 75% clopidogrel, and 73% combination treatment. Conclusion There was considerable country-variation in ACS management. These results provide a benchmark of physician practice to compare with guidelines.