Carbamazepine induced DRESS syndrome

We present here an 18-yr-old male who presented with intermittent fever of moderate grade and of 15 days duration, followed by maculopapular erythematous rashes over upper and lower extremities, face, and trunk developing over 10-12 days. He was suffering from recurrent seizures since last 3 months...

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Veröffentlicht in:Journal of the Association of Physicians of India 2010-10, Vol.58, p.634-636
Hauptverfasser: Chauhan, Ajay, Anand, Swati, Thomas, Sindha, Subramanya, H C A, Pradhan, Gyanranjan
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creator Chauhan, Ajay
Anand, Swati
Thomas, Sindha
Subramanya, H C A
Pradhan, Gyanranjan
description We present here an 18-yr-old male who presented with intermittent fever of moderate grade and of 15 days duration, followed by maculopapular erythematous rashes over upper and lower extremities, face, and trunk developing over 10-12 days. He was suffering from recurrent seizures since last 3 months for which he was started on carbamazepine 200mg twice daily for the past 6 weeks. He was febrile on admission. Generalized lymphadenopathy with discreet, non-matted, firm and tender inguinal lymph nodes. Patch test with 1% and 5% solution of carbamazepine was strongly positive.
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
subjects Adolescent
Anticonvulsants - adverse effects
Biopsy
Carbamazepine - adverse effects
Dermatitis, Exfoliative - chemically induced
Dermatitis, Exfoliative - complications
Drug Eruptions
Drug Hypersensitivity
Eosinophilia - chemically induced
Eosinophilia - complications
Epilepsy - drug therapy
Exanthema - chemically induced
Exanthema - complications
Humans
Hyperthermia, Induced
Lymphatic Diseases - chemically induced
Lymphatic Diseases - complications
Male
Patch Tests
Skin Tests
Syndrome
Treatment Outcome
title Carbamazepine induced DRESS syndrome
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