Carbamazepine induced DRESS syndrome

We present here an 18-yr-old male who presented with intermittent fever of moderate grade and of 15 days duration, followed by maculopapular erythematous rashes over upper and lower extremities, face, and trunk developing over 10-12 days. He was suffering from recurrent seizures since last 3 months...

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Veröffentlicht in:	Journal of the Association of Physicians of India 2010-10, Vol.58, p.634-636
Hauptverfasser:	Chauhan, Ajay, Anand, Swati, Thomas, Sindha, Subramanya, H C A, Pradhan, Gyanranjan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Anticonvulsants - adverse effects Biopsy Carbamazepine - adverse effects Dermatitis, Exfoliative - chemically induced Dermatitis, Exfoliative - complications Drug Eruptions Drug Hypersensitivity Eosinophilia - chemically induced Eosinophilia - complications Epilepsy - drug therapy Exanthema - chemically induced Exanthema - complications Humans Hyperthermia, Induced Lymphatic Diseases - chemically induced Lymphatic Diseases - complications Male Patch Tests Skin Tests Syndrome Treatment Outcome
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Beschreibung
Zusammenfassung:	We present here an 18-yr-old male who presented with intermittent fever of moderate grade and of 15 days duration, followed by maculopapular erythematous rashes over upper and lower extremities, face, and trunk developing over 10-12 days. He was suffering from recurrent seizures since last 3 months for which he was started on carbamazepine 200mg twice daily for the past 6 weeks. He was febrile on admission. Generalized lymphadenopathy with discreet, non-matted, firm and tender inguinal lymph nodes. Patch test with 1% and 5% solution of carbamazepine was strongly positive.
ISSN:	0004-5772