Placental alkaline phosphatase in pediatric adrenocortical cancer

The germline R337H mutation in the TP53 gene is considered to be responsible for the increased incidence of adrenocortical tumors (ACTs) in children from Brazil. High level production of hormones in ACTs (>95%) cause virilization alone (60%), Cushing syndrome (

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pediatric hematology/oncology 2011-05, Vol.33 (4), p.e149-e153
Hauptverfasser:	Boechat, Giovanna Assis Pereira, Stinghen, Sérvio Túlio, Custódio, Gislaine, Pianovski, Mara Albonei Dudeque, Figueiredo, Francisco Ricardo de Oliveira, Jenkins, Jesse, Zambetti, Gerard P, Ribeiro, Raul C, Figueiredo, Bonald C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex - embryology Adrenal Cortex - metabolism Adrenal Cortex Neoplasms - genetics Adrenal Cortex Neoplasms - metabolism Adrenal Cortex Neoplasms - pathology Alkaline Phosphatase - metabolism Apoptosis - physiology Child Female Germ-Line Mutation GPI-Linked Proteins - metabolism Humans Immunohistochemistry Isoenzymes - metabolism Male Tumor Suppressor Protein p53 - genetics
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Beschreibung
Zusammenfassung:	The germline R337H mutation in the TP53 gene is considered to be responsible for the increased incidence of adrenocortical tumors (ACTs) in children from Brazil. High level production of hormones in ACTs (>95%) cause virilization alone (60%), Cushing syndrome (
ISSN:	1077-4114 1536-3678
DOI:	10.1097/MPH.0b013e3182099a80