Successful fertility management of a patient with factor V deficiency: planned transfusion of fresh frozen plasma under infertility treatment

Objective To report the case of a patient with factor V deficiency who achieved pregnancy with the planned transfusion of fresh frozen plasma (FFP) while monitoring follicle development and ovulation induction using gonadotropin. Design Case report. Setting University hospital. Patient(s) A 28-year-old nulliparous female. Intervention(s) Medical management including infertility treatment. Main Outcome Measure(s) Clinical follow-up. Result(s) A patient with factor V deficiency experienced repeated ovulation-related hemoperitoneum following the withdrawal of oral contraceptive pills. The monitoring of follicle development and ovulation induction using gonadotropin followed by FFP transfusion was useful to avoid hemoperitoneum. Pregnancy was achieved within a relatively short period using intrauterine insemination. Conclusion(s) Planned prophylactic FFP administration and intervention with infertility treatment might be useful to minimize the risk of ovulation-related hemoperitoneum in patients with factor V deficiency.