Induced Pluripotent Stem Cells: An Emerging Theranostics Platform

Nuclear reprogramming generates induced pluripotent stem (iPS) cells endowed with the unlimited potential to reconstruct genetically identical tissues. This biomedical tool offers unprecedented opportunities to develop scalable yet personalized cell‐based reagents. The emerging platform of regenerat...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2011-05, Vol.89 (5), p.648-650
Hauptverfasser:	Nelson, TJ, Terzic, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Differentiation - physiology Cellular Reprogramming - physiology Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - transplantation Regenerative Medicine - methods Regenerative Medicine - trends
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Beschreibung
Zusammenfassung:	Nuclear reprogramming generates induced pluripotent stem (iPS) cells endowed with the unlimited potential to reconstruct genetically identical tissues. This biomedical tool offers unprecedented opportunities to develop scalable yet personalized cell‐based reagents. The emerging platform of regenerative theranostics provides a unique approach to expose mechanisms of disease etiology in the context of dysfunctional cell biology. Resolved molecular dynamics that define and regulate the regenerative capacity of individual stem cells will enable next‐generation, patient‐specific diagnostic and therapeutic applications. Clinical Pharmacology & Therapeutics (2011) 89 5, 648–650. doi:10.1038/clpt.2010.304
ISSN:	0009-9236 1532-6535
DOI:	10.1038/clpt.2010.304