Lipid-Free Apolipoprotein A-I and Discoidal Reconstituted High-Density Lipoproteins Differentially Inhibit Glucose-Induced Oxidative Stress in Human Macrophages

OBJECTIVE—The goal of this study was to investigate the mechanisms by which apolipoprotein (apo) A-I, in the lipid-free form or as a constituent of discoidal reconstituted high-density lipoproteins ([A-I]rHDL), inhibits high-glucose–induced redox signaling in human monocyte-derived macrophages (HMDM...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2011-05, Vol.31 (5), p.1192-1200
Hauptverfasser:	Tabet, Fatiha, Lambert, Gilles, Cuesta Torres, Luisa F, Hou, Liming, Sotirchos, Irene, Touyz, Rhian M, Jenkins, Alicia J, Barter, Philip J, Rye, Kerry-Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Apolipoprotein A-I - metabolism Atherosclerosis (general aspects, experimental research) ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter, Sub-Family G, Member 1 ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biological and medical sciences Blood and lymphatic vessels Blotting, Western Cardiology. Vascular system Case-Control Studies Cells, Cultured Diabetes Mellitus, Type 2 - immunology Diabetes Mellitus, Type 2 - metabolism Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Enzyme Inhibitors - pharmacology General and cellular metabolism. Vitamins Glucose - metabolism Humans Lipoproteins - metabolism Lipoproteins, HDL - metabolism Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Medical sciences Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism NADPH Oxidase 2 NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - genetics NADPH Oxidases - metabolism Oxidative Stress - drug effects Pharmacology. Drug treatments Protein Transport Reverse Transcriptase Polymerase Chain Reaction RNA Interference RNA, Messenger - metabolism Scavenger Receptors, Class B - genetics Scavenger Receptors, Class B - metabolism Signal Transduction Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase-1 Superoxides - metabolism Time Factors Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!