In vitro Activities of Erythromycin, Tetracycline and Levofloxacin Alone and in Dual Combinations against Ureaplasma spp

Purpose: It was the aim of our study to evaluate the in vitro activities of tetracycline (TET), erythromycin (ERY) and levofloxacin (LVX) alone and in dual combinations against ureaplasmas. Methods: The minimum inhibitory concentrations (MICs) of 51 ureaplasmal strains were determined by microdilution assay. Results: TET was the most active when the antibiotics were used alone. The combinations resulted in significantly decreased MICs for every agent compared with the use of single antibiotics (p < 0.05, respectively), except for ERY in the ERY-LVX pair (p > 0.05), and decreased the MICs more significantly in the strains with an MIC ≧4 mg/l compared with MIC