CpG oligodeoxynucleotides containing GACGTT motifs enhance the immune responses elicited by a goose parvovirus vaccine in ducks

Abstract Recombinant parvovirus VP2 (rVP2) was formulated with different types of adjuvant, including aluminum adjuvant and CpG oligodeoxynucleotides (ODNs), and the immunological responses after vaccination in ducks were examined. In comparison with the control group, production of rVP2-specific an...

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Veröffentlicht in:	Vaccine 2010-11, Vol.28 (50), p.7956-7962
Hauptverfasser:	Lee, Jai-Wei, Lin, Yu-Ming, Yen, Ting-Ying, Yang, Wen-Jen, Chu, Chun-Yen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants, Immunologic - pharmacology Allergy and Immunology Aluminum Animals Antibodies, Viral - blood Applied microbiology Aquatic birds Biological and medical sciences Capsid Proteins - immunology CD4-CD8 Ratio Cell Proliferation CpG Cytokines - immunology Deoxyribonucleic acid DNA Duck Ducks Ducks - immunology Fundamental and applied biological sciences. Psychology Genomes Goose parvovirus Immune system Immunization Leukocytes, Mononuclear - immunology Lymphocytes Microbiology Miscellaneous Oligodeoxyribonucleotides - immunology Parvoviridae Infections - prevention & control Parvoviridae Infections - veterinary Parvovirus Parvovirus - immunology Poultry Diseases - prevention & control Proteins Recombinant Recombinant Proteins - immunology Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral infections Virology
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Zusammenfassung:	Abstract Recombinant parvovirus VP2 (rVP2) was formulated with different types of adjuvant, including aluminum adjuvant and CpG oligodeoxynucleotides (ODNs), and the immunological responses after vaccination in ducks were examined. In comparison with the control group, production of rVP2-specific antibodies, expression of cytokines in peripheral blood mononuclear cells (PBMC) stimulated by rVP2, and percentage of CD4+ /CD8+ cells in PBMC were significantly increased in ducks immunized with rVP2 formulated with CpG ODNs containing 3 copies of GACGTT motif. CpG ODNs with GACGTT motifs might be used to improve the efficacy of vaccines for ducks.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2010.09.072