Hair cells in non-vertebrate models: Lower chordates and molluscs

The study of hair cells in invertebrates is important, because it can shed light on the debated question about the evolutionary origin of vertebrate hair cells. Here, we review the morphology and significance of hair cells in two groups of invertebrates, the lower chordates (tunicates and cephalochordates) and the molluscs. These taxa possess complex mechanoreceptor organs based on both primary (sensory neurons) and/or secondary, axonless, sensory cells, bearing various apical specializations. Compared with vertebrates, these taxa show interesting examples of convergent evolution and possible homologies of sensory systems. For example, the “lateral line organ” of Octopoda and Decapoda, composed of primary sensory cells aligned on the arms and the head, is considered a classic example of convergent evolution to mechanoreception. Similarly, in ascidians, the cupular organ, formed of primary sensory cells embedded in a gelatinous cupula, is seen as an analog of neuromasts in vertebrates. However, the coronal organ of the oral siphon of ascidians, represented by a line of secondary sensory cells with a hair bundle also comprising graded stereovilli, is currently the best candidate for tracing the evolutionary origin of the vertebrate octavo-lateralis system. Several features, such as embryological origin, position, gene expression and morphology, support this hypothesis.