The chemokine receptor CCR5 in the central nervous system

The expression and the role of the chemokine receptor CCR5 have been mainly studied in the context of HIV infection. However, this protein is also expressed in the brain, where it can be crucial in determining the outcome in response to different insults. CCR5 expression can be deleterious or protec...

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Veröffentlicht in:	Progress in neurobiology 2011-02, Vol.93 (2), p.297-311
Hauptverfasser:	Sorce, Silvia, Myburgh, Renier, Krause, Karl-Heinz
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival Central Nervous System - immunology HIV Infections - drug therapy HIV Infections - immunology Human immunodeficiency virus Humans Models, Molecular Neurons - cytology Neurons - immunology Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - immunology Receptors, CCR5 - chemistry Receptors, CCR5 - genetics Receptors, CCR5 - immunology
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Beschreibung
Zusammenfassung:	The expression and the role of the chemokine receptor CCR5 have been mainly studied in the context of HIV infection. However, this protein is also expressed in the brain, where it can be crucial in determining the outcome in response to different insults. CCR5 expression can be deleterious or protective in controlling the progression of certain infections in the CNS, but it is also emerging that it could play a role in non-infectious diseases. In particular, it appears that, in addition to modulating immune responses, CCR5 can influence neuronal survival. Here, we summarize the present knowledge about the expression of CCR5 in the brain and highlight recent findings suggesting its possible involvement in neuroprotective mechanisms.
ISSN:	0301-0082 1873-5118
DOI:	10.1016/j.pneurobio.2010.12.003