Elevated umbilical cord serum TARC/CCL17 levels predict the development of atopic dermatitis in infancy
Cite this as: H. Miyahara, N. Okazaki,T. Nagakura, S. Korematsu and T. Izumi,Clinical & Experimental Allergy, 2011 (41) 186–191. Summary Background Thymus‐and‐activation‐regulated chemokine (TARC; CCL17) is related to both allergy and pregnancy, but the relationships of maternal and umbilical co...
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| description | Cite this as: H. Miyahara, N. Okazaki,T. Nagakura, S. Korematsu and T. Izumi,Clinical & Experimental Allergy, 2011 (41) 186–191.
Summary
Background
Thymus‐and‐activation‐regulated chemokine (TARC; CCL17) is related to both allergy and pregnancy, but the relationships of maternal and umbilical cord blood CCL17 to atopic dermatitis (AD) development have not yet been examined.
Objective
Seventy paired full‐term and normal vaginal delivery newborns and their mothers were enrolled in this study.
Methods
To elucidate the pathogenesis and fetomaternal inheritance of AD in infancy, CCL17, IFN‐γ‐inducible protein 10 kDa (IP‐10; CXCL10), soluble HLA‐G (sHLA‐G), IgE and eosinophil counts were examined using sera from 70 paired umbilical cord and maternal blood samples.
Results
Serum CCL17 (rs=0.340, P |
| doi_str_mv | 10.1111/j.1365-2222.2010.03634.x |
| format | Article |
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Summary
Background
Thymus‐and‐activation‐regulated chemokine (TARC; CCL17) is related to both allergy and pregnancy, but the relationships of maternal and umbilical cord blood CCL17 to atopic dermatitis (AD) development have not yet been examined.
Objective
Seventy paired full‐term and normal vaginal delivery newborns and their mothers were enrolled in this study.
Methods
To elucidate the pathogenesis and fetomaternal inheritance of AD in infancy, CCL17, IFN‐γ‐inducible protein 10 kDa (IP‐10; CXCL10), soluble HLA‐G (sHLA‐G), IgE and eosinophil counts were examined using sera from 70 paired umbilical cord and maternal blood samples.
Results
Serum CCL17 (rs=0.340, P<0.001) and sHLA‐G (rs=0.600, P<0.001) levels showed high correlations between umbilical cord and maternal blood. Umbilical cord serum levels of CCL17 from neonates destined to develop AD in infancy were higher than in those from neonates who showed no signs of AD during infancy (median 1586.9 vs. 819.6 pg/mL, P<0.001). Serum levels of CCL17 were higher in mothers with AD than in those without AD (median 909.6 vs. 214.1 pg/mL, P<0.001). High umbilical cord serum levels of CCL17 were associated with infantile AD development even in 62 neonates born to mothers without AD (median 1514.4 vs. 740.6 pg/mL, P<0.001) and 38 neonates born to mothers with no allergies (median 1624.2 vs. 740.6 pg/mL, P<0.001). The summary estimates for umbilical cord serum CCL17 in the diagnosis of infantile AD were: sensitivity 85.7% (95% confidence interval: 72.8–98.7), specificity 73.8% (60.5–87.1), positive predictive value 68.6% (53.2–84.0) and negative predictive value 88.6% (78.0–99.1).
Conclusion and Clinical Relevance
These findings suggest that the umbilical cord blood CCL17 may be involved in the pathogenesis of infantile AD and in fetomaternal inheritance. Serum levels of CCL17 from umbilical cord blood may be a predictive marker for AD in infancy.]]></description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/j.1365-2222.2010.03634.x</identifier><identifier>PMID: 21054588</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Age of Onset ; Allergic diseases ; Atopic dermatitis ; Biological and medical sciences ; Biomarkers - blood ; Case-Control Studies ; CCL17 ; CCL17 protein ; Chemokine CCL17 - blood ; chemokine TARC ; Child, Preschool ; Confidence intervals ; CXCL10 protein ; Dermatitis, Atopic - blood ; Dermatitis, Atopic - congenital ; Female ; Fetal Blood - chemistry ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; gamma -Interferon ; Heredity ; Histocompatibility antigen HLA ; Humans ; Hypersensitivity ; Immunoglobulin E ; Immunopathology ; Infant ; Infant, Newborn ; IP-10 protein ; Leukocytes (eosinophilic) ; Male ; Medical sciences ; Neonates ; Pathogenesis ; Predictive Value of Tests ; Pregnancy ; Prognosis ; Reproducibility of Results ; Serum levels ; Skin allergic diseases. Stinging insect allergies ; Stem cells ; TARC ; Umbilical cord ; umbilical cord blood ; Vagina</subject><ispartof>Clinical and experimental allergy, 2011-02, Vol.41 (2), p.186-191</ispartof><rights>2010 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2010 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5624-b3f179029e2fe6b6334f685f573adafbbe2af51abbe1a986c1e8be3dc8d101523</citedby><cites>FETCH-LOGICAL-c5624-b3f179029e2fe6b6334f685f573adafbbe2af51abbe1a986c1e8be3dc8d101523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2222.2010.03634.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2222.2010.03634.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23730031$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21054588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyahara, H.</creatorcontrib><creatorcontrib>Okazaki, N.</creatorcontrib><creatorcontrib>Nagakura, T.</creatorcontrib><creatorcontrib>Korematsu, S.</creatorcontrib><creatorcontrib>Izumi, T.</creatorcontrib><title>Elevated umbilical cord serum TARC/CCL17 levels predict the development of atopic dermatitis in infancy</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description><![CDATA[Cite this as: H. Miyahara, N. Okazaki,T. Nagakura, S. Korematsu and T. Izumi,Clinical & Experimental Allergy, 2011 (41) 186–191.
Summary
Background
Thymus‐and‐activation‐regulated chemokine (TARC; CCL17) is related to both allergy and pregnancy, but the relationships of maternal and umbilical cord blood CCL17 to atopic dermatitis (AD) development have not yet been examined.
Objective
Seventy paired full‐term and normal vaginal delivery newborns and their mothers were enrolled in this study.
Methods
To elucidate the pathogenesis and fetomaternal inheritance of AD in infancy, CCL17, IFN‐γ‐inducible protein 10 kDa (IP‐10; CXCL10), soluble HLA‐G (sHLA‐G), IgE and eosinophil counts were examined using sera from 70 paired umbilical cord and maternal blood samples.
Results
Serum CCL17 (rs=0.340, P<0.001) and sHLA‐G (rs=0.600, P<0.001) levels showed high correlations between umbilical cord and maternal blood. Umbilical cord serum levels of CCL17 from neonates destined to develop AD in infancy were higher than in those from neonates who showed no signs of AD during infancy (median 1586.9 vs. 819.6 pg/mL, P<0.001). Serum levels of CCL17 were higher in mothers with AD than in those without AD (median 909.6 vs. 214.1 pg/mL, P<0.001). High umbilical cord serum levels of CCL17 were associated with infantile AD development even in 62 neonates born to mothers without AD (median 1514.4 vs. 740.6 pg/mL, P<0.001) and 38 neonates born to mothers with no allergies (median 1624.2 vs. 740.6 pg/mL, P<0.001). The summary estimates for umbilical cord serum CCL17 in the diagnosis of infantile AD were: sensitivity 85.7% (95% confidence interval: 72.8–98.7), specificity 73.8% (60.5–87.1), positive predictive value 68.6% (53.2–84.0) and negative predictive value 88.6% (78.0–99.1).
Conclusion and Clinical Relevance
These findings suggest that the umbilical cord blood CCL17 may be involved in the pathogenesis of infantile AD and in fetomaternal inheritance. Serum levels of CCL17 from umbilical cord blood may be a predictive marker for AD in infancy.]]></description><subject>Adult</subject><subject>Age of Onset</subject><subject>Allergic diseases</subject><subject>Atopic dermatitis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>CCL17</subject><subject>CCL17 protein</subject><subject>Chemokine CCL17 - blood</subject><subject>chemokine TARC</subject><subject>Child, Preschool</subject><subject>Confidence intervals</subject><subject>CXCL10 protein</subject><subject>Dermatitis, Atopic - blood</subject><subject>Dermatitis, Atopic - congenital</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>gamma -Interferon</subject><subject>Heredity</subject><subject>Histocompatibility antigen HLA</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Immunoglobulin E</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>IP-10 protein</subject><subject>Leukocytes (eosinophilic)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neonates</subject><subject>Pathogenesis</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Prognosis</subject><subject>Reproducibility of Results</subject><subject>Serum levels</subject><subject>Skin allergic diseases. Stinging insect allergies</subject><subject>Stem cells</subject><subject>TARC</subject><subject>Umbilical cord</subject><subject>umbilical cord blood</subject><subject>Vagina</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2P0zAQhi0EYrsLfwFZQohTunYcJ_aBQxXKgqgALYv2aDnOGFzytXbCtv8eh5YicYGRJY_Gz-sZ-0UIU7KkMS63S8pynqQxlimJVcJyli13D9DidPAQLYjkWVIImZ2h8xC2hBDGpXiMzlJKeMaFWKCv6wZ-6BFqPLWVa5zRDTa9r3EAP7X4ZnVdXpblhhY4ctAEPHionRnx-A1wPZf6oYVuxL3FeuwHZ2LVt3p0owvYdXFZ3Zn9E_TI6ibA0-N-gb68Wd-Ub5PNx6t35WqTGJ6nWVIxSwtJUgmphbzKGctsLrjlBdO1tlUFqbac6phQLUVuKIgKWG1ETQnlKbtALw_3Dr6_myCMqnXBQNPoDvopKJGnhaAFE_8ms_hblEkZyed_kdt-8l18hootJSeRopESB8r4PgQPVg3etdrvFSVqdk1t1WyOms1Rs2vql2tqF6XPjg2mqoX6JPxtUwReHAEdokPWxy914Q_HCha9nWd4deDuXQP7_x5AlevVnEV9ctC7MMLupNf-u8oLVnB1--FK3b6-fv9ZfsoUYz8B03LAyQ</recordid><startdate>201102</startdate><enddate>201102</enddate><creator>Miyahara, H.</creator><creator>Okazaki, N.</creator><creator>Nagakura, T.</creator><creator>Korematsu, S.</creator><creator>Izumi, T.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201102</creationdate><title>Elevated umbilical cord serum TARC/CCL17 levels predict the development of atopic dermatitis in infancy</title><author>Miyahara, H. ; Okazaki, N. ; Nagakura, T. ; Korematsu, S. ; Izumi, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5624-b3f179029e2fe6b6334f685f573adafbbe2af51abbe1a986c1e8be3dc8d101523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Allergic diseases</topic><topic>Atopic dermatitis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>CCL17</topic><topic>CCL17 protein</topic><topic>Chemokine CCL17 - blood</topic><topic>chemokine TARC</topic><topic>Child, Preschool</topic><topic>Confidence intervals</topic><topic>CXCL10 protein</topic><topic>Dermatitis, Atopic - blood</topic><topic>Dermatitis, Atopic - congenital</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>gamma -Interferon</topic><topic>Heredity</topic><topic>Histocompatibility antigen HLA</topic><topic>Humans</topic><topic>Hypersensitivity</topic><topic>Immunoglobulin E</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>IP-10 protein</topic><topic>Leukocytes (eosinophilic)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neonates</topic><topic>Pathogenesis</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Prognosis</topic><topic>Reproducibility of Results</topic><topic>Serum levels</topic><topic>Skin allergic diseases. Stinging insect allergies</topic><topic>Stem cells</topic><topic>TARC</topic><topic>Umbilical cord</topic><topic>umbilical cord blood</topic><topic>Vagina</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyahara, H.</creatorcontrib><creatorcontrib>Okazaki, N.</creatorcontrib><creatorcontrib>Nagakura, T.</creatorcontrib><creatorcontrib>Korematsu, S.</creatorcontrib><creatorcontrib>Izumi, T.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyahara, H.</au><au>Okazaki, N.</au><au>Nagakura, T.</au><au>Korematsu, S.</au><au>Izumi, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated umbilical cord serum TARC/CCL17 levels predict the development of atopic dermatitis in infancy</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>2011-02</date><risdate>2011</risdate><volume>41</volume><issue>2</issue><spage>186</spage><epage>191</epage><pages>186-191</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract><![CDATA[Cite this as: H. Miyahara, N. Okazaki,T. Nagakura, S. Korematsu and T. Izumi,Clinical & Experimental Allergy, 2011 (41) 186–191.
Summary
Background
Thymus‐and‐activation‐regulated chemokine (TARC; CCL17) is related to both allergy and pregnancy, but the relationships of maternal and umbilical cord blood CCL17 to atopic dermatitis (AD) development have not yet been examined.
Objective
Seventy paired full‐term and normal vaginal delivery newborns and their mothers were enrolled in this study.
Methods
To elucidate the pathogenesis and fetomaternal inheritance of AD in infancy, CCL17, IFN‐γ‐inducible protein 10 kDa (IP‐10; CXCL10), soluble HLA‐G (sHLA‐G), IgE and eosinophil counts were examined using sera from 70 paired umbilical cord and maternal blood samples.
Results
Serum CCL17 (rs=0.340, P<0.001) and sHLA‐G (rs=0.600, P<0.001) levels showed high correlations between umbilical cord and maternal blood. Umbilical cord serum levels of CCL17 from neonates destined to develop AD in infancy were higher than in those from neonates who showed no signs of AD during infancy (median 1586.9 vs. 819.6 pg/mL, P<0.001). Serum levels of CCL17 were higher in mothers with AD than in those without AD (median 909.6 vs. 214.1 pg/mL, P<0.001). High umbilical cord serum levels of CCL17 were associated with infantile AD development even in 62 neonates born to mothers without AD (median 1514.4 vs. 740.6 pg/mL, P<0.001) and 38 neonates born to mothers with no allergies (median 1624.2 vs. 740.6 pg/mL, P<0.001). The summary estimates for umbilical cord serum CCL17 in the diagnosis of infantile AD were: sensitivity 85.7% (95% confidence interval: 72.8–98.7), specificity 73.8% (60.5–87.1), positive predictive value 68.6% (53.2–84.0) and negative predictive value 88.6% (78.0–99.1).
Conclusion and Clinical Relevance
These findings suggest that the umbilical cord blood CCL17 may be involved in the pathogenesis of infantile AD and in fetomaternal inheritance. Serum levels of CCL17 from umbilical cord blood may be a predictive marker for AD in infancy.]]></abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21054588</pmid><doi>10.1111/j.1365-2222.2010.03634.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Clinical and experimental allergy, 2011-02, Vol.41 (2), p.186-191 |
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| subjects | Adult Age of Onset Allergic diseases Atopic dermatitis Biological and medical sciences Biomarkers - blood Case-Control Studies CCL17 CCL17 protein Chemokine CCL17 - blood chemokine TARC Child, Preschool Confidence intervals CXCL10 protein Dermatitis, Atopic - blood Dermatitis, Atopic - congenital Female Fetal Blood - chemistry Fundamental and applied biological sciences. Psychology Fundamental immunology gamma -Interferon Heredity Histocompatibility antigen HLA Humans Hypersensitivity Immunoglobulin E Immunopathology Infant Infant, Newborn IP-10 protein Leukocytes (eosinophilic) Male Medical sciences Neonates Pathogenesis Predictive Value of Tests Pregnancy Prognosis Reproducibility of Results Serum levels Skin allergic diseases. Stinging insect allergies Stem cells TARC Umbilical cord umbilical cord blood Vagina |
| title | Elevated umbilical cord serum TARC/CCL17 levels predict the development of atopic dermatitis in infancy |
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