Elevated umbilical cord serum TARC/CCL17 levels predict the development of atopic dermatitis in infancy

Cite this as: H. Miyahara, N. Okazaki,T. Nagakura, S. Korematsu and T. Izumi,Clinical & Experimental Allergy, 2011 (41) 186–191. Summary Background Thymus‐and‐activation‐regulated chemokine (TARC; CCL17) is related to both allergy and pregnancy, but the relationships of maternal and umbilical cord blood CCL17 to atopic dermatitis (AD) development have not yet been examined. Objective Seventy paired full‐term and normal vaginal delivery newborns and their mothers were enrolled in this study. Methods To elucidate the pathogenesis and fetomaternal inheritance of AD in infancy, CCL17, IFN‐γ‐inducible protein 10 kDa (IP‐10; CXCL10), soluble HLA‐G (sHLA‐G), IgE and eosinophil counts were examined using sera from 70 paired umbilical cord and maternal blood samples. Results Serum CCL17 (rs=0.340, P