The importance of the N-H bond in Ru/TsDPEN complexes for asymmetric transfer hydrogenation of ketones and imines

The importance of the N-H bond in Ru/TsDPEN complexes for asymmetric transfer hydrogenation of ketones and imines

Ru(II) complexes of TsDPEN containing two alkyl groups on the non-tosylated nitrogen atom are poor catalysts for asymmetric transfer hydrogenation of ketones and imines; this observation provides direct evidence for the importance of the N-H interaction in the transition state for ketone reduction.

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Veröffentlicht in:Organic & biomolecular chemistry 2011-05, Vol.9 (9), p.3290-3294
Hauptverfasser: Soni, Rina, Cheung, Fung Kei, Clarkson, Guy C, Martins, Jose E D, Graham, Mark A, Wills, Martin
Format: Artikel
Sprache:eng
Schlagworte:
Ethylenediamines - chemistry
Hydrogen - chemistry
Hydrogenation
Imines - chemistry
Ketones - chemistry
Molecular Structure
Nitrogen - chemistry
Organometallic Compounds - chemistry
Oxidation-Reduction
Stereoisomerism
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Zusammenfassung:Ru(II) complexes of TsDPEN containing two alkyl groups on the non-tosylated nitrogen atom are poor catalysts for asymmetric transfer hydrogenation of ketones and imines; this observation provides direct evidence for the importance of the N-H interaction in the transition state for ketone reduction.
ISSN:1477-0520
1477-0539
DOI:10.1039/c1ob05208j