Mechanism of glutaredoxin-ISU [2Fe-2S] cluster exchange

Mechanism of glutaredoxin-ISU [2Fe-2S] cluster exchange

Exchange of [2Fe-2S] centers between Grx2 and the cluster scaffold protein ISU, and characterization of two mutually exclusive Grx2 binding sites on ISU by isothermal titration calorimetry supports a direct link for Grx and glutathione involvement in ISU promoted Fe-S cluster biosynthesis.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2011-01, Vol.47 (17), p.4989-4991
Hauptverfasser: Qi, Wenbin, Cowan, J A
Format: Artikel
Sprache:eng
Schlagworte:
Binding Sites
Biosynthesis
Calorimetry, Differential Scanning
Clusters
Glutaredoxins - metabolism
Glutathione Disulfide - metabolism
Humans
Iron
Iron - metabolism
Iron-Sulfur Proteins - metabolism
Kinetics
Links
Proteins
Scaffolds
Sulfur - metabolism
Thermodynamics
Titration calorimetry
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Beschreibung
Zusammenfassung:Exchange of [2Fe-2S] centers between Grx2 and the cluster scaffold protein ISU, and characterization of two mutually exclusive Grx2 binding sites on ISU by isothermal titration calorimetry supports a direct link for Grx and glutathione involvement in ISU promoted Fe-S cluster biosynthesis.
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc05079b