A new three-component reaction: green synthesis of novel isoindolo[2,1-a]quinazoline derivatives as potent inhibitors of TNF-α

Concurrent construction of five and six membered fused N-heretocyclic ring was achieved via a conceptually new three-component reaction affording 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-diones as novel inhibitors of TNF-αin vitro. This represents one of the few examples of direct TNF-α inhibiti...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2011-05, Vol.47 (17), p.5010-5012
Hauptverfasser:	Kumar, K Siva, Kumar, P Mahesh, Kumar, K Anil, Sreenivasulu, M, Jafar, Ahamed A, Rambabu, D, Krishna, G Rama, Reddy, C Malla, Kapavarapu, Ravikumar, Shivakumar, K, Priya, K Krishna, Parsa, Kishore V L, Pal, Manojit
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biomarkers Green Chemistry Technology Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - pharmacology Heterocyclic Compounds - therapeutic use Humans Inflammation - drug therapy Isoindoles - chemistry Isoindoles - pharmacology Isoindoles - therapeutic use Quinazolines - chemical synthesis Quinazolines - pharmacology Quinazolines - therapeutic use Structure-Activity Relationship Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism
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Beschreibung
Zusammenfassung:	Concurrent construction of five and six membered fused N-heretocyclic ring was achieved via a conceptually new three-component reaction affording 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-diones as novel inhibitors of TNF-αin vitro. This represents one of the few examples of direct TNF-α inhibition by small molecules.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c1cc10715a