Structure elucidation and biosynthesis of lysine-rich cyclic peptides in Xenorhabdus nematophila

Structure elucidation and biosynthesis of lysine-rich cyclic peptides in Xenorhabdus nematophila

Thirteen novel PAX (peptide-antimicrobial-Xenorhabdus) peptides were identified in Xenorhabdus nematophila HGB081. Their structures including the absolute configuration were elucidated using a combination of labeling experiments, detailed MS/MS experiments, the advanced Marfey's method, and a d...

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Veröffentlicht in:Organic & biomolecular chemistry 2011-05, Vol.9 (9), p.3130-3132
Hauptverfasser: Fuchs, Sebastian W, Proschak, Anna, Jaskolla, Thorsten W, Karas, Michael, Bode, Helge B
Format: Artikel
Sprache:eng
Schlagworte:
Lysine - chemistry
Molecular Structure
Peptides, Cyclic - biosynthesis
Peptides, Cyclic - chemistry
Xenorhabdus - chemistry
Xenorhabdus - metabolism
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Zusammenfassung:Thirteen novel PAX (peptide-antimicrobial-Xenorhabdus) peptides were identified in Xenorhabdus nematophila HGB081. Their structures including the absolute configuration were elucidated using a combination of labeling experiments, detailed MS/MS experiments, the advanced Marfey's method, and a detailed analysis of the biosynthesis gene cluster, which was identified as well.
ISSN:1477-0520
1477-0539
DOI:10.1039/c1ob05097d