New Antifungal Xanthones from the Seeds of Rhus coriaria L

Phytochemical investigations of the ethanolic extract of the seeds of Rhus coriaria L. (Anacardiaceae) led to the identification of four new xanthones, characterized as 2,3-dihydroxy- 7-methyl xanthone (1), 2,3,6-trihydroxy-7-hydroxymethylene xanthone-1-carboxylic acid (2), 2-methoxy-4-hydroxy-7-methyl-3-O-β-D-glucopyranosyl xanthone-1,8-dicarboxylic acid (4), and 2-hydroxy-7-hydroxymethylene xanthone-1,8-dicarboxylic acid 3-O-β-D-glucopyranosyl- (2’ → 3’’)-3’’-O-stigmast-5-ene (5), along with the known steroidal glucoside β-sitosterol-β-Dglucoside (3). The structures of the isolated compounds have been identifi ed on the basis of spectral data analysis and chemical reactions. All xanthones were active against Aspergillus flavus.