Hard x-ray Zernike microscopy reaches 30 nm resolution

Hard x-ray Zernike microscopy reaches 30 nm resolution

Since its invention in 1930, Zernike phase contrast has been a pillar in optical microscopy and more recently in x-ray microscopy, in particular for low-absorption-contrast biological specimens. We experimentally demonstrate that hard-x-ray Zernike microscopy now reaches a lateral resolution below 3...

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Veröffentlicht in:Opt. Lett 2011-04, Vol.36 (7), p.1269-1271
Hauptverfasser: CHEN, Yu-Tung, CHEN, Tsung-Yu, YI, Jaemock, CHU, Yong S, LEE, Wah-Keat, WANG, Cheng-Liang, KEMPSON, Ivan M, HWU, Y, GAJDOSIK, Vincent, MARGARITONDO, G
Format: Artikel
Sprache:eng
Schlagworte:
Animals
BASIC BIOLOGICAL SCIENCES
Cell Line, Tumor
Coculture Techniques
Exact sciences and technology
Fundamental areas of phenomenology (including applications)
GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
Gold - chemistry
INVENTIONS
Metal Nanoparticles
Mice
MICROSCOPY
Microscopy - methods
OPENINGS
OPTICAL MICROSCOPY
Optics
Physics
Polystyrenes - chemistry
RESOLUTION
X-Rays
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Beschreibung
Zusammenfassung:Since its invention in 1930, Zernike phase contrast has been a pillar in optical microscopy and more recently in x-ray microscopy, in particular for low-absorption-contrast biological specimens. We experimentally demonstrate that hard-x-ray Zernike microscopy now reaches a lateral resolution below 30 nm while strongly enhancing the contrast, thus opening many new research opportunities in biomedicine and materials science.
ISSN:0146-9592
1539-4794
DOI:10.1364/ol.36.001269