Phenytoin at optimum doses ameliorates experimental autoimmune encephalomyelitis via modulation of immunoregulatory cells

Abstract We investigated the optimum doses of phenytoin for treatment of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE). Oral and intraperitoneal administrations of 0.25 to 1.0 mg per mouse (12.5–50 mg/kg) 3 times a week improved the clinical course. Intr...

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Veröffentlicht in:	Journal of neuroimmunology 2011-04, Vol.233 (1), p.112-119
Hauptverfasser:	Hashiba, Naomi, Nagayama, Shigemi, Araya, Shin-ich, Inada, Hiroyuki, Sonobe, Yoshifumi, Suzumura, Akio, Matsui, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Anticonvulsants - therapeutic use CD127 CD8 Disease Models, Animal EAE Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Immunologic Factors - therapeutic use Mice Mice, Inbred C57BL Neurology Phenytoin Phenytoin - therapeutic use Regulatory T cells T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology
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Zusammenfassung:	Abstract We investigated the optimum doses of phenytoin for treatment of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE). Oral and intraperitoneal administrations of 0.25 to 1.0 mg per mouse (12.5–50 mg/kg) 3 times a week improved the clinical course. Intraperitoneal injections of 1.0 mg phenytoin were the most effective, as a significant reduction in EAE severity was seen after only 2 administrations with that protocol. Treatment efficacy was associated with amelioration of cellular infiltrates in the CNS, and an increase in CD4+ Foxp3+ and CD4+ CD25+ CD127− regulatory T cells as well as CD8+ suppressor/cytotoxic T cells in blood.
ISSN:	0165-5728 1872-8421
DOI:	10.1016/j.jneuroim.2010.12.006