The role of STAT5 in the development, function, and transformation of B and T lymphocytes

The transcription factor signal transducer and activator of transcription 5 (STAT5) is activated by a number of cytokine and growth hormone receptors and plays a key role in the development and function of many organ systems. In this review, we focus on recent discoveries about the role of STAT5 in...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2011-01, Vol.1217 (1), p.18-31
Hauptverfasser:	Heltemes-Harris, Lynn M., Willette, Mark J. L., Vang, Kieng B., Farrar, Michael A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - metabolism Cell Differentiation - immunology Growth hormones Humans leukemia Lymphocyte Activation - immunology lymphocyte development Lymphocytes lymphoma STAT5 STAT5 Transcription Factor - physiology T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism transformation
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Beschreibung
Zusammenfassung:	The transcription factor signal transducer and activator of transcription 5 (STAT5) is activated by a number of cytokine and growth hormone receptors and plays a key role in the development and function of many organ systems. In this review, we focus on recent discoveries about the role of STAT5 in the development and function of B and T lymphocytes. Of particular interest is the growing appreciation for the function of STAT5 as a transcriptional repressor. Finally, we discuss recent discoveries about the role of STAT5 in transformation of B and T lymphocytes.
ISSN:	0077-8923 1749-6632
DOI:	10.1111/j.1749-6632.2010.05907.x