Synthesis, characterization and antimicrobial properties of a Co(II)-phthalylsulfathiazolate complex

The reaction between phthalylsulfathiazole (H₂PST), in alkaline aqueous solution, and cobalt(II) nitrate led to a pink solid, [Co(PST)(H₂O)₄] (1), which was characterized by elemental and thermogravimetric analysis; FT-IR, Raman and diffuse reflectance spectra. Spectroscopic data reveal that the lig...

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Veröffentlicht in:	Biometals 2010-12, Vol.23 (6), p.1015-1028
Hauptverfasser:	Monti, Laura, Pontoriero, Ana, Mosconi, Natalia, Giulidori, Cecilia, Hure, Estela, Williams, Patricia A. M, Rodríguez, María Victoria, Feresin, Gabriela, Campagnoli, Darío, Rizzotto, Marcela
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology antibacterial properties Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology antifungal properties Aqueous chemistry Biochemistry Biomedical and Life Sciences Cell Biology Chemical reactions Chemical synthesis Cobalt Cobalt - chemistry Cobalt complexes Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - pharmacology Hemolysis - drug effects Humans Life Sciences Medicine/Public Health Microbial Sensitivity Tests Microbiology Molecular Structure Mutagenicity Tests Onions - drug effects Onions - genetics Pharmacology/Toxicology Phthalylsulfathiazole Plant Physiology Spectroscopy, Fourier Transform Infrared Spectrum analysis Spectrum Analysis, Raman Sulfadrugs metal complexes
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Zusammenfassung:	The reaction between phthalylsulfathiazole (H₂PST), in alkaline aqueous solution, and cobalt(II) nitrate led to a pink solid, [Co(PST)(H₂O)₄] (1), which was characterized by elemental and thermogravimetric analysis; FT-IR, Raman and diffuse reflectance spectra. Spectroscopic data reveal that the ligand would be doubly deprotonated and that the Co(II) ion environment is a distorted octahedral one. (1) showed antibacterial activity similar to the ligand.
ISSN:	0966-0844 1572-8773
DOI:	10.1007/s10534-010-9347-8