Biosynthesis of 2-Alkyl-4(1H)-Quinolones in Pseudomonas aeruginosa: Potential for Therapeutic Interference with Pathogenicity

Targeting quorum sensing: The Pseudomonas quinolone signal (PQS) and its direct precursor HHQ are important quorum‐sensing signal molecules in P. aeruginosa that contribute to the pathogenicity of this bacterium. In vitro reconstitution of HHQ biosynthesis employing recombinant PqsD protein has shed...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2011-04, Vol.12 (6), p.850-853
Hauptverfasser:	Pistorius, Dominik, Ullrich, Angelika, Lucas, Simon, Hartmann, Rolf W., Kazmaier, Uli, Müller, Rolf
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Quinolones - metabolism Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - genetics Bacterial Proteins - metabolism biosynthesis inhibitors Drug Discovery HHQ formation Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - enzymology Pseudomonas aeruginosa - pathogenicity Quorum Sensing Recombinant Proteins - antagonists & inhibitors Recombinant Proteins - genetics Recombinant Proteins - metabolism
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Zusammenfassung:	Targeting quorum sensing: The Pseudomonas quinolone signal (PQS) and its direct precursor HHQ are important quorum‐sensing signal molecules in P. aeruginosa that contribute to the pathogenicity of this bacterium. In vitro reconstitution of HHQ biosynthesis employing recombinant PqsD protein has shed light on this enzyme and its substrates, and led to a test system for identifying inhibitors.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.201100014