One-Pot Reactions Accelerate the Synthesis of Active Pharmaceutical Ingredients
All in one: A one‐pot synthesis of the dipeptidylpeptidase IV selective inhibitor ABT‐341 (see structure) by using an “uninterrupted sequence of reactions” has been developed. This strategy broadens the spectrum of one‐pot reactions and is poised to speed up the synthesis of medicinally relevant dru...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2011-04, Vol.50 (16), p.3605-3607 |
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| container_issue | 16 |
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| container_title | Angewandte Chemie International Edition |
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| creator | Vaxelaire, Carine Winter, Philipp Christmann, Mathias |
| description | All in one: A one‐pot synthesis of the dipeptidylpeptidase IV selective inhibitor ABT‐341 (see structure) by using an “uninterrupted sequence of reactions” has been developed. This strategy broadens the spectrum of one‐pot reactions and is poised to speed up the synthesis of medicinally relevant drug compounds. |
| doi_str_mv | 10.1002/anie.201100059 |
| format | Article |
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| ispartof | Angewandte Chemie International Edition, 2011-04, Vol.50 (16), p.3605-3607 |
| issn | 1433-7851 1521-3773 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Biphenyl Compounds - chemical synthesis Biphenyl Compounds - chemistry Catalysis Dipeptidyl Peptidase 4 - chemistry Dipeptidyl Peptidase 4 - metabolism Dipeptidyl-Peptidase IV Inhibitors - chemical synthesis Dipeptidyl-Peptidase IV Inhibitors - chemistry drug synthesis one-pot reactions organocatalysis Oseltamivir - chemical synthesis Oseltamivir - chemistry Pharmaceutical Preparations - chemical synthesis Pharmaceutical Preparations - chemistry Stereoisomerism sustainable chemistry Triazoles - chemical synthesis Triazoles - chemistry |
| title | One-Pot Reactions Accelerate the Synthesis of Active Pharmaceutical Ingredients |
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