One-Pot Reactions Accelerate the Synthesis of Active Pharmaceutical Ingredients

One-Pot Reactions Accelerate the Synthesis of Active Pharmaceutical Ingredients

All in one: A one‐pot synthesis of the dipeptidylpeptidase IV selective inhibitor ABT‐341 (see structure) by using an “uninterrupted sequence of reactions” has been developed. This strategy broadens the spectrum of one‐pot reactions and is poised to speed up the synthesis of medicinally relevant dru...

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Veröffentlicht in:Angewandte Chemie International Edition 2011-04, Vol.50 (16), p.3605-3607
Hauptverfasser: Vaxelaire, Carine, Winter, Philipp, Christmann, Mathias
Format: Artikel
Sprache:eng
Schlagworte:
Biphenyl Compounds - chemical synthesis
Biphenyl Compounds - chemistry
Catalysis
Dipeptidyl Peptidase 4 - chemistry
Dipeptidyl Peptidase 4 - metabolism
Dipeptidyl-Peptidase IV Inhibitors - chemical synthesis
Dipeptidyl-Peptidase IV Inhibitors - chemistry
drug synthesis
one-pot reactions
organocatalysis
Oseltamivir - chemical synthesis
Oseltamivir - chemistry
Pharmaceutical Preparations - chemical synthesis
Pharmaceutical Preparations - chemistry
Stereoisomerism
sustainable chemistry
Triazoles - chemical synthesis
Triazoles - chemistry
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Beschreibung
Zusammenfassung:All in one: A one‐pot synthesis of the dipeptidylpeptidase IV selective inhibitor ABT‐341 (see structure) by using an “uninterrupted sequence of reactions” has been developed. This strategy broadens the spectrum of one‐pot reactions and is poised to speed up the synthesis of medicinally relevant drug compounds.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201100059