Izumiphenazine D, a New Phenazoquinoline N-Oxide from Streptomyces sp. IFM 11204

A new phenazine derivative named izumiphenazine D (1), together with three known metabolites, 1-hydroxyphenazine (2), phenazine-1-carboxylic acid (3) and 6-hydroxyphenazine-1-carboxylic acid (4) has been isolated from the ethyl acetate extract of culture of Streptomyces sp. IFM 11204. The structure...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2011/04/01, Vol.59(4), pp.508-510
Hauptverfasser:	Abdelfattah, Mohamed S., Toume, Kazufumi, Ishibashi, Masami
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Humans Molecular Conformation N-oxide Oxides - chemistry Oxides - isolation & purification Oxides - toxicity phenazine Quinolines - chemistry Quinolines - isolation & purification Quinolines - toxicity spectroscopy Streptomyces - chemistry Streptomyces sp TNF-Related Apoptosis-Inducing Ligand - pharmacology
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Zusammenfassung:	A new phenazine derivative named izumiphenazine D (1), together with three known metabolites, 1-hydroxyphenazine (2), phenazine-1-carboxylic acid (3) and 6-hydroxyphenazine-1-carboxylic acid (4) has been isolated from the ethyl acetate extract of culture of Streptomyces sp. IFM 11204. The structure of 1 was established via spectroscopic methods, including 1D- and 2D-NMR measurements.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.59.508