Chronic exposure to ambient particulate matter alters cardiac gene expression patterns and markers of oxidative stress in rats

Exposure to ambient particulate matter (PM) significantly increases cardiovascular morbidity and mortality in the general population. We hypothesized that some components of PM can affect the gene expression patterns in the hearts of rats exposed for 3 months to filtered air (FA), coarse (CP; 2.5 ...

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Veröffentlicht in:	Air quality, atmosphere and health atmosphere and health, 2011-03, Vol.4 (1), p.15-25
Hauptverfasser:	Simkhovich, Boris Z., Kleinman, Michael T., Mehrian-Shai, Ruty, Hsu, Ya-Hsuan, Meacher, Dianne, Gookin, Glenn, Kinnon, Michael Mac, Salazar, Karina, Willet, Paul, Feng, Gang, Lin, Simon M., Kloner, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Air pollution Air quality Airborne particulates Antioxidants Apoptosis Atmospheric pollution Atmospheric pollution and health Atmospheric Protection/Air Quality Control/Air Pollution Bioindicators biomarkers Cardiovascular disease Cardiovascular diseases Chronic exposure Correlations Earth and Environmental Science Environment Environmental Health Enzymes Exposure Gene expression Growth factors Health Promotion and Disease Prevention Heart Heart diseases Heart failure Hospitals Laboratory animals Malonaldehyde Medical research Medicine Metabolism Morbidity Mortality Mutation Myocardium Outdoor air quality Oxidative stress Particulate air pollutants Particulate matter Particulates Pollutants Polymerase chain reaction Protein folding Protein turnover Rats Statistical analysis Thioredoxin
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Zusammenfassung:	Exposure to ambient particulate matter (PM) significantly increases cardiovascular morbidity and mortality in the general population. We hypothesized that some components of PM can affect the gene expression patterns in the hearts of rats exposed for 3 months to filtered air (FA), coarse (CP; 2.5
ISSN:	1873-9318 1873-9326
DOI:	10.1007/s11869-010-0089-0