Effects of co-administration of artesunate and amodiaquine on some cardiovascular disease indices in rats

The effects of co-administration of artesunate and amodiaquine on some cardiovascular disease indices were investigated in albino rats (Rattus novergicus). The experimental animals were randomly divided into four groups: those administered distilled water (control), those administered artesunate (2mg/kg body weight), those administered amodiaquine (6.12mg/kg body weight) and those co-administered artesunate (2mg/kg body weight) and amodiaquine (6.12mg/kg body weight). The drugs were orally administered twice daily for three days after which the serum lipid profile, heart MDA content and heart ALP and ACP activities were determined. Artesunate significantly reduced (P0.05) on other parameters compared to controls. Amodiaquine, on the other hand, significantly reduced (P