Environmental-benign oxidation of 2-oxazolines to oxazoles by dioxygen as the sole oxidant

Environmental-benign oxidation of 2-oxazolines to oxazoles by dioxygen as the sole oxidant

A facile and environment-benign oxidation by dioxygen as the sole oxidant was applied for the conversion of 2-oxazolines to oxazoles. The substituent effect on 2-oxazoline ring was investigated. The use of this methodology for the synthesis of a key intermediate of a CDC25 phosphatase inhibitor ( SC...

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Veröffentlicht in:Tetrahedron 2011-03, Vol.67 (11), p.2066-2071
Hauptverfasser: Huang, Yue, Ni, Lijun, Gan, Haifeng, He, Yu, Xu, Jinyi, Wu, Xiaoming, Yao, Hequan
Format: Artikel
Sprache:eng
Schlagworte:
2-Oxazolines
Antineoplastic agents
Biological and medical sciences
Chemistry
Conversion
Dioxygen
Environmental-benign
Exact sciences and technology
General aspects
Heterocyclic compounds
Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms
Inhibitors
Medical sciences
Organic chemistry
Oxazole
Oxazoles
Oxidants
Oxidation
Oxidizing agents
Pharmacology. Drug treatments
Preparations and properties
Sole
Tetrahedrons
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Zusammenfassung:A facile and environment-benign oxidation by dioxygen as the sole oxidant was applied for the conversion of 2-oxazolines to oxazoles. The substituent effect on 2-oxazoline ring was investigated. The use of this methodology for the synthesis of a key intermediate of a CDC25 phosphatase inhibitor ( SC- ααδ9) as an anticancer agent was also described. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2011.01.050