Identification of 17,20β,21-trihydroxy-4-pregnen-3-one (20β-S) receptor binding and membrane progestin receptor alpha on southern flounder sperm ( Paralichthys lethostigma ) and their likely role in 20β-S stimulation of sperm hypermotility

Research highlights ► Show direct action of progestins to increase sperm motility for the first time in a non-Sciaenid fish. ► We present evidence that membrane progestin receptor alpha mediates this phenomenon. ► Data suggest that direct progestin actions are of widespread physiological significanc...

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Veröffentlicht in:	General and comparative endocrinology 2011-02, Vol.170 (3), p.629-639
Hauptverfasser:	Tubbs, Christopher, Tan, Wenxian, Shi, Bao, Thomas, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	adenylate cyclase Amino Acid Sequence Animals binding sites Cortodoxone - analogs & derivatives Cortodoxone - metabolism Cortodoxone - pharmacology Dideoxyadenosine - analogs & derivatives Dideoxyadenosine - pharmacology Endocrinology & Metabolism Flounder Flounder - metabolism guanosine Male Marine Membrane progestin receptor alpha Molecular Sequence Data Paralichthys lethostigma Pleuronectiformes progestational hormones Progestin binding Progestins proteins Receptors, Progesterone - metabolism Sciaenidae Sequence Alignment Sperm hypermotility sperm motility Sperm Motility - drug effects spermatozoa steroids Teleost Teleostei thin layer chromatography
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Zusammenfassung:	Research highlights ► Show direct action of progestins to increase sperm motility for the first time in a non-Sciaenid fish. ► We present evidence that membrane progestin receptor alpha mediates this phenomenon. ► Data suggest that direct progestin actions are of widespread physiological significance in fishes.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2010.12.005