Grape seed proanthocyanidin extract (GSPE) differentially regulates Foxp3+ regulatory and IL-17+ pathogenic T cell in autoimmune arthritis
Research highlights ▶ Grape seed proanthocyanidin extract (GSPE), which is the antioxidant derived from grape seeds. ▶ GSPE decreased the frequency of IL-17/Th17 cells. ▶ GSPE increased the frequency of Foxp3/Treg cells. ▶ GSPE differentially regulate Th17 and Treg cell subsets in mice and human sys...
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| Veröffentlicht in: | Immunology letters 2011-03, Vol.135 (1), p.50-58 |
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| container_title | Immunology letters |
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| creator | Park, Mi-Kyung Park, Jin-Sil Cho, Mi-La Oh, Hye-Jwa Heo, Yu-Jung Woo, Yun-Ju Heo, Yang-Mi Park, Min-Jung Park, Hyun-Sil Park, Sung-Hwan Kim, Ho-Youn Min, Jun-Ki |
| description | Research highlights ▶ Grape seed proanthocyanidin extract (GSPE), which is the antioxidant derived from grape seeds. ▶ GSPE decreased the frequency of IL-17/Th17 cells. ▶ GSPE increased the frequency of Foxp3/Treg cells. ▶ GSPE differentially regulate Th17 and Treg cell subsets in mice and human system. |
| doi_str_mv | 10.1016/j.imlet.2010.09.011 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-fe26559e40e2ff8331df84bf96baf41a967967dc4fbcc4848376dc3c02a14a23</citedby><cites>FETCH-LOGICAL-c445t-fe26559e40e2ff8331df84bf96baf41a967967dc4fbcc4848376dc3c02a14a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165247810002476$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20933009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Mi-Kyung</creatorcontrib><creatorcontrib>Park, Jin-Sil</creatorcontrib><creatorcontrib>Cho, Mi-La</creatorcontrib><creatorcontrib>Oh, Hye-Jwa</creatorcontrib><creatorcontrib>Heo, Yu-Jung</creatorcontrib><creatorcontrib>Woo, Yun-Ju</creatorcontrib><creatorcontrib>Heo, Yang-Mi</creatorcontrib><creatorcontrib>Park, Min-Jung</creatorcontrib><creatorcontrib>Park, Hyun-Sil</creatorcontrib><creatorcontrib>Park, Sung-Hwan</creatorcontrib><creatorcontrib>Kim, Ho-Youn</creatorcontrib><creatorcontrib>Min, Jun-Ki</creatorcontrib><title>Grape seed proanthocyanidin extract (GSPE) differentially regulates Foxp3+ regulatory and IL-17+ pathogenic T cell in autoimmune arthritis</title><title>Immunology letters</title><addtitle>Immunol Lett</addtitle><description>Research highlights ▶ Grape seed proanthocyanidin extract (GSPE), which is the antioxidant derived from grape seeds. ▶ GSPE decreased the frequency of IL-17/Th17 cells. ▶ GSPE increased the frequency of Foxp3/Treg cells. ▶ GSPE differentially regulate Th17 and Treg cell subsets in mice and human system.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>Arthritis</subject><subject>Arthritis, Experimental - drug therapy</subject><subject>Arthritis, Experimental - immunology</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Autoimmune arthritis</subject><subject>Autoimmune diseases</subject><subject>CD4 antigen</subject><subject>Collagen</subject><subject>Collagen (type II)</subject><subject>Cytokines - immunology</subject><subject>Differentiation</subject><subject>Foxp3</subject><subject>Foxp3 protein</subject><subject>Grape seed proanthocyanidin extract (GSPE)</subject><subject>Helper cells</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammatory diseases</subject><subject>Interleukin 17</subject><subject>Interleukin 21</subject><subject>Interleukin 22</subject><subject>Joint diseases</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Mice</subject><subject>Pathogenic T cells</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>proanthocyanidins</subject><subject>Proanthocyanidins - chemistry</subject><subject>Proanthocyanidins - pharmacology</subject><subject>Regulatory T cells</subject><subject>Rheumatoid arthritis</subject><subject>Seeds</subject><subject>Seeds - chemistry</subject><subject>Splenocytes</subject><subject>Stat3 protein</subject><subject>T-Lymphocytes, Regulatory</subject><subject>Th17</subject><subject>Th17 Cells</subject><subject>Vitaceae</subject><subject>Vitis - chemistry</subject><issn>0165-2478</issn><issn>1879-0542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt9qFDEUxoModq0-gSC5Uymznkwy_y4qSGnXwoJC9z5kMydt1pnMmGSk8wo-tRm39cKbQuDA4fu-JOd3CHnLYM2AlZ8Oa9t3GNc5pA40a2DsGVmxumoyKET-nKySqshyUdUn5FUIBwBWcMFfkpMcGs4BmhX5vfFqRBoQWzr6Qbl4N-hZOdtaR_E-eqUj_bC5-X75kbbWGPToolVdN1OPt1OnIgZ6NdyP_OyxMfiZKtfS623GqjM6qhR5i85quqMau46mZDXFwfb95JAqH--8jTa8Ji-M6gK-eainZHd1ubv4mm2_ba4vvmwzLUQRM4N5WRQNCsDcmJpz1ppa7E1T7pURTDVllU6rhdlrLWpR86psNdeQKyZUzk_J-2Ns-u7PCUOUvQ3Lu5TDYQqyLoFXKVY8rRSV4KxiSyY_KrUfQvBo5Ohtr_wsGcgFljzIv7DkAktCIxOs5Hr3kD_te2z_eR7pJMH5UYBpHL8sehm0RaextR51lO1gn7jg839-3dkEQnU_cMZwGCbv0qQlkyGXIG-WfVnWhQFAqiX_A_qtvHA</recordid><startdate>20110330</startdate><enddate>20110330</enddate><creator>Park, Mi-Kyung</creator><creator>Park, Jin-Sil</creator><creator>Cho, Mi-La</creator><creator>Oh, Hye-Jwa</creator><creator>Heo, Yu-Jung</creator><creator>Woo, Yun-Ju</creator><creator>Heo, Yang-Mi</creator><creator>Park, Min-Jung</creator><creator>Park, Hyun-Sil</creator><creator>Park, Sung-Hwan</creator><creator>Kim, Ho-Youn</creator><creator>Min, Jun-Ki</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20110330</creationdate><title>Grape seed proanthocyanidin extract (GSPE) differentially regulates Foxp3+ regulatory and IL-17+ pathogenic T cell in autoimmune arthritis</title><author>Park, Mi-Kyung ; Park, Jin-Sil ; Cho, Mi-La ; Oh, Hye-Jwa ; Heo, Yu-Jung ; Woo, Yun-Ju ; Heo, Yang-Mi ; Park, Min-Jung ; Park, Hyun-Sil ; Park, Sung-Hwan ; Kim, Ho-Youn ; Min, Jun-Ki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-fe26559e40e2ff8331df84bf96baf41a967967dc4fbcc4848376dc3c02a14a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - pharmacology</topic><topic>Arthritis</topic><topic>Arthritis, Experimental - drug therapy</topic><topic>Arthritis, Experimental - immunology</topic><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Autoimmune arthritis</topic><topic>Autoimmune diseases</topic><topic>CD4 antigen</topic><topic>Collagen</topic><topic>Collagen (type II)</topic><topic>Cytokines - immunology</topic><topic>Differentiation</topic><topic>Foxp3</topic><topic>Foxp3 protein</topic><topic>Grape seed proanthocyanidin extract (GSPE)</topic><topic>Helper cells</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammatory diseases</topic><topic>Interleukin 17</topic><topic>Interleukin 21</topic><topic>Interleukin 22</topic><topic>Joint diseases</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Mice</topic><topic>Pathogenic T cells</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>proanthocyanidins</topic><topic>Proanthocyanidins - chemistry</topic><topic>Proanthocyanidins - pharmacology</topic><topic>Regulatory T cells</topic><topic>Rheumatoid arthritis</topic><topic>Seeds</topic><topic>Seeds - chemistry</topic><topic>Splenocytes</topic><topic>Stat3 protein</topic><topic>T-Lymphocytes, Regulatory</topic><topic>Th17</topic><topic>Th17 Cells</topic><topic>Vitaceae</topic><topic>Vitis - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Mi-Kyung</creatorcontrib><creatorcontrib>Park, Jin-Sil</creatorcontrib><creatorcontrib>Cho, Mi-La</creatorcontrib><creatorcontrib>Oh, Hye-Jwa</creatorcontrib><creatorcontrib>Heo, Yu-Jung</creatorcontrib><creatorcontrib>Woo, Yun-Ju</creatorcontrib><creatorcontrib>Heo, Yang-Mi</creatorcontrib><creatorcontrib>Park, Min-Jung</creatorcontrib><creatorcontrib>Park, Hyun-Sil</creatorcontrib><creatorcontrib>Park, Sung-Hwan</creatorcontrib><creatorcontrib>Kim, Ho-Youn</creatorcontrib><creatorcontrib>Min, Jun-Ki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - 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| fulltext | fulltext |
| identifier | ISSN: 0165-2478 |
| ispartof | Immunology letters, 2011-03, Vol.135 (1), p.50-58 |
| issn | 0165-2478 1879-0542 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Allergy and Immunology Animals Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Arthritis Arthritis, Experimental - drug therapy Arthritis, Experimental - immunology Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Autoimmune arthritis Autoimmune diseases CD4 antigen Collagen Collagen (type II) Cytokines - immunology Differentiation Foxp3 Foxp3 protein Grape seed proanthocyanidin extract (GSPE) Helper cells Humans Inflammation Inflammatory diseases Interleukin 17 Interleukin 21 Interleukin 22 Joint diseases Lymphocytes T Male Mice Pathogenic T cells Plant Extracts - chemistry Plant Extracts - pharmacology proanthocyanidins Proanthocyanidins - chemistry Proanthocyanidins - pharmacology Regulatory T cells Rheumatoid arthritis Seeds Seeds - chemistry Splenocytes Stat3 protein T-Lymphocytes, Regulatory Th17 Th17 Cells Vitaceae Vitis - chemistry |
| title | Grape seed proanthocyanidin extract (GSPE) differentially regulates Foxp3+ regulatory and IL-17+ pathogenic T cell in autoimmune arthritis |
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