Grape seed proanthocyanidin extract (GSPE) differentially regulates Foxp3+ regulatory and IL-17+ pathogenic T cell in autoimmune arthritis

Research highlights ▶ Grape seed proanthocyanidin extract (GSPE), which is the antioxidant derived from grape seeds. ▶ GSPE decreased the frequency of IL-17/Th17 cells. ▶ GSPE increased the frequency of Foxp3/Treg cells. ▶ GSPE differentially regulate Th17 and Treg cell subsets in mice and human sys...

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Veröffentlicht in:	Immunology letters 2011-03, Vol.135 (1), p.50-58
Hauptverfasser:	Park, Mi-Kyung, Park, Jin-Sil, Cho, Mi-La, Oh, Hye-Jwa, Heo, Yu-Jung, Woo, Yun-Ju, Heo, Yang-Mi, Park, Min-Jung, Park, Hyun-Sil, Park, Sung-Hwan, Kim, Ho-Youn, Min, Jun-Ki
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Arthritis Arthritis, Experimental - drug therapy Arthritis, Experimental - immunology Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Autoimmune arthritis Autoimmune diseases CD4 antigen Collagen Collagen (type II) Cytokines - immunology Differentiation Foxp3 Foxp3 protein Grape seed proanthocyanidin extract (GSPE) Helper cells Humans Inflammation Inflammatory diseases Interleukin 17 Interleukin 21 Interleukin 22 Joint diseases Lymphocytes T Male Mice Pathogenic T cells Plant Extracts - chemistry Plant Extracts - pharmacology proanthocyanidins Proanthocyanidins - chemistry Proanthocyanidins - pharmacology Regulatory T cells Rheumatoid arthritis Seeds Seeds - chemistry Splenocytes Stat3 protein T-Lymphocytes, Regulatory Th17 Th17 Cells Vitaceae Vitis - chemistry
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Beschreibung
Zusammenfassung:	Research highlights ▶ Grape seed proanthocyanidin extract (GSPE), which is the antioxidant derived from grape seeds. ▶ GSPE decreased the frequency of IL-17/Th17 cells. ▶ GSPE increased the frequency of Foxp3/Treg cells. ▶ GSPE differentially regulate Th17 and Treg cell subsets in mice and human system.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2010.09.011