Enhancement of radiation effect by heavy elements

The enhancement of radiobiological effects by heavy elements is reviewed. As an underlying mechanism, Auger effects have been stressed which can be induced via inner-shell photoabsorption or via excitation and/or ionization by secondary electrons. Latter channel of Auger induction expands the applic...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Mutation research 2010-04, Vol.704 (1), p.123-131
Hauptverfasser:	Kobayashi, K., Usami, N., Porcel, E., Lacombe, S., Le Sech, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Auger effect Biological and medical sciences Cancer therapy Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Drug Delivery Systems Electrons - therapeutic use Fundamental and applied biological sciences. Psychology Heavy elements Humans Molecular and cellular biology Molecular genetics Mutagenesis. Repair Nanoparticle Nanoparticles Photons Plasmids Radiation Effects Radiation-Sensitizing Agents - pharmacology Radiobiological enhancement Radiobiology - methods Radiotherapy - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The enhancement of radiobiological effects by heavy elements is reviewed. As an underlying mechanism, Auger effects have been stressed which can be induced via inner-shell photoabsorption or via excitation and/or ionization by secondary electrons. Latter channel of Auger induction expands the applicability of Auger enhancing phenomena to electron and hadron therapy. After discussion on the required characteristics for radiosensitizers, possibility of nanoparticles of Au or Pt is mentioned since they could be synthesized or modified as ideal radiosensitizers.
ISSN:	1383-5742 0027-5107 1388-2139
DOI:	10.1016/j.mrrev.2010.01.002